Relationship between tryptophan metabolism and the state of melaninogensis
Kurbanov, K.
Biulleten' Eksperimental'noi Biologii i Meditsiny 82(12): 1441-1444
1976
ISSN/ISBN: 0365-9615 PMID: 1023970 Document Number: 101841
In studying the excretion of tryptophan and the activity of tryptophan pyrrholase of the liver in black and albino rabbits it was revealed that the kinurenine, kinurenic and xanthurenic acids, 3-hydroxykinurenin, anthranylic acid and 5-hydroxyindolylactic acid levels in the urine collected before the L-tryptophane loading differed in these animals. No 3-hydroxyanthranylic acid was found in the initial urine of these rabbits. A sharp intensification of excretion of all the tryptophane metabolites studied followed the administration of L-tryptophane to albino rabbits, and a harper elevation of kinurenic and xanthurenic acid excretion--to black rabbits. In comparison with black rabbits, the tryptophan pyrrholase of the liver of albino rabbits reached to the L-tryptophan administration more intensively.