Metabolism and serum levels of tryptophan in senile cataract patients
Costa, C.; Angi, M.R.; De Carli, M.; Vanzan, S.; Allegri, G.
Bollettino della Societa Italiana di Biologia Sperimentale 58(6): 333-339
1982
ISSN/ISBN: 0037-8771 PMID: 7082472 Document Number: 193155
In order to clarify the role of tryptophan in the patogenesis of senile cataract, we have studied the serum total and free levels of tryptophan in cataract patients as compared with age and sex-matched controls, and the urinary excretion of 10 metabolites after oral load of the amino acid. This excretion increases in the cataract group both as total per cent and as kynurenine. No difference has been found in the free and total serum tryptophan between normal subjects and cataract patients. A possible role of the kynurenines in the pathogenesis of senile cataract is suggested.