Interaction of indolmycin in the metabolism of tryptophan in rat liver
Werner, R.G.; Reuter, W.
Arzneimittel-Forschung 29(1): 59-63
1979
ISSN/ISBN: 0004-4172 PMID: 582120 Document Number: 145064
When compared with other tryptophan analogues, indolmycin is a potent inhibitor of tryptophan pyrrolase and tryptophan decarboxylase, both enzymes involved in tryptophan catabolism. Otherwise the decarboxylation of 5-hydroxytryptophan is only slightly affected by indolmycin. The indolmycin derivative, 2-methylamino-5-(1-naphthylmethyl)-oxazolidin-4-one (YX-CX 22 XX) demonstrates only a slightly weaker inhibitory effect in the tryptophan-tRNA-ligase system in E. coli but does not show any significant action on the tryptophan metabolism in the eukaryotic system.