Impairment of human polymorphonuclear leucocyte function by influenza virus
Larson, H.E.; Blades, R.
Lancet 1(7954): 283
1976
ISSN/ISBN: 0140-6736 PMID: 55591 Document Number: 101741
The effects of an influenza virus on polymorphonuclear leucocyte [PMN] function were examined in vitro with respect to why bacterial pneumonia often accompanies influenza in man. The ability of human PMN to show chemotaxis and to phagocytize staphylococci was inhibited when they were incubated with influenza viruses. Hexose monophosphate shunt activation was unaffected. The inhibitory effects were apparently specific to the virus.
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