Penetration of phenylacetic acid across the blood-cerebrospinal fluid barrier
Pedemonte, W.A.; Mosnaim, A.D.; Bulat, M.
Research Communications in Chemical Pathology and Pharmacology 14(1): 111-116
1976
ISSN/ISBN: 0034-5164 PMID: 935645 Document Number: 101500
Labeled phenylacetic acid (14C-PAA) penetrates blood-cerebrospinal fluid (CSF) barrier in cats only under a high gradient of concentration; under these conditions the administration of large doses of either PAA or probenecid decreases the plasma:CSF 14C-PAA ratio. 14C-PAA is quickly removed from the CSF and blood and is excreted into urine; this excretion is blocked by probenecid. It appears, therefore, that PAA crosses the blood-CSF barrier with difficulty and that is secreted by the kidney.