Experimental allergic encephalitis (EAE) in mice: histological studies on EAE induced by myelin basic protein, and role of pertussis vaccine
Mitsuzawa, E.; Yasuda, T.
Japanese Journal of Experimental Medicine 46(4): 205-212
1976
ISSN/ISBN: 0021-5031 PMID: 62860 Document Number: 101328
The histological evidence of EAE in mice was presented to show the identity with those of other species of animals. There was a typical perivascular mononuclear cell infiltration. In addition, a hyperacute form was characterized by edema and the infiltration of polymorphs. In vascular lesions, vascular stasis, thrombosis, and hemorrhage were observed. As for the effect of pertussis vaccine used in the induction of mouse EAE, responsiveness to the histamine sensitizing factor was not directly correlated to the incidence of EAE. However, the intravenous administration of pertussis vaccine caused remarkable leukocytosis, which might play a certain role in mouse EAE induction.