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Clinical pharmacokinetics of 2-C14-ftorafur in patients with astrocytoma

Apinis, T.A.; Zilbere, A.M.; Meĭrena, D.V.; Gilev, A.P.; Zhuk, R.A.

Voprosy Onkologii 22(7): 20-24

1976

ISSN/ISBN: 0507-3758
PMID: 793170
Document Number: 100685
Patients with dedifferentiated brain astrocytoma during an operation were injected intravenously 2-C14-fluorofur (3 muC/Kg). In different periods after the injection the level of radioactivity was determined in different sites of the tumor, brain tissue, as well as in blood plasma, cerebrospinal liquor and urine. Intracellular localization of the labeled substance in the tumor tissue was examined autohistoradiographically. 2-C14-fluorofur was found to readily penetrate the hemato-encephalic barrier and to be absorbed both by tissues of neuroectodermal tumor and adjacent brain tissues. In astrocytoma cells the labelled substance is localized mainly extranuclearly. Radioactive products are excreted from the organism slowly and their traces are observed in blood, cerebrospinal liquor and urine even on the third day postoperatively.

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