Phase i trial of ftorafur combined with mitomycin C or methyl-CCNU in gastrointestinal cancers
Buroker, T.; Baker, L.; Correa, J.; Schwartz, L.A.; Vailtkevicius, V.K.
Cancer Treatment Reports 61(3): 463-467
1977
ISSN/ISBN: 0361-5960 PMID: 326403 Document Number: 118242
Twenty-five patients with disseminated gastrointestinal malignancies were treated in a phase I study with a combination of ftorafur and mitomycin C or florafur and methyl-CCNU. Most patients had been heavily treated previously. Gastrointestinal, central nervous system, and marrow toxicity were manageable. Tumor regression was noted in five of 25 patients. A large-scale phase II study in untreated patients with gastrointestinal malignancies appears indicated with a combination of these agents.