Experimental study of the antitumor activity of nitrosomethylurea, adriablastine and ftorafur on model gliomas with different growth rates
Romodanov, A.P.; Zhmareva, E.N.; Butsenko, O.I.
Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 4: 11-19
1983
ISSN/ISBN: 0042-8817 PMID: 6414203 Document Number: 206395
A marked antitumor effect of the agents studied was demonstrated in experiments on three strains of gliomas of the brain of rats (two rapidly-growing and one slowly-growing tumor). Phthorafur increased the survival of the animals with one of the rapidly-growing tumors (strain No. 35) and often had a marked side effect. Adriablastin inhibited the development of rapidly-growing gliomas but was ineffective in experiments with slowly-growing glioma. NMU considerably increased the survival of the animals in all experiments but recovery was not encountered. In treatment with NMU, a cell population resistant to this agent occurred in the gliomas. A new glioma strain was obtained during the experiments; it was insensitive to therapeutic doses of NMU and differed in morphology from the initial highly-sensitive tumor (strain No. 2211). The prospects of using agents of the nitrosomethyl urea group in the chemotherapy of gliomas are discussed.