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Effect of diuretics (diacarb and lasix) on the experimental antitumor activity, toxicity and pharmacokinetics of the antibiotic, olivomycin

Stepanova, E.S.; Liashenko, V.A.

Antibiotiki 23(7): 617-621

1978

ISSN/ISBN: 0003-5637
PMID: 581050
Document Number: 131192
Diacarb or lasix in combination with olivomycin increased the antibiotic antiblastomic activity and toxicity when used for the course treatment of mice with transplanted lymphosarcoma LIO-I. The chemotherapeutic indices of such combinations did not differ from those of olivomycin used alone. Diacarb decreased excretion of olivomycin with the urine in healthy mice, while lasix increased it.

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Pitina, L.R.; Baranov, E.P.; Grinchenko, B.I.; Brikenshteĭn, B.K.; Barenboĭm, G.M. 1981: Interaction of the antitumor antibiotic olivomycin with Mg2+ ions Antibiotiki 26(12): 906-912
Israel, M.; Modest, E.J.; Frei, E. 1975: N-trifluoroacetyladriamycin-14-valerate, an analog with greater experimental antitumor activity and less toxicity than adriamycin Cancer Research 35(5): 1365-1368
Dorr, R.T.; Alberts, D.S.; Einspahr, J.; Mason-Liddil, N.; Soble, M. 1987: Experimental dacarbazine antitumor activity and skin toxicity in relation to light exposure and pharmacologic antidotes Cancer Treatment Reports 71(3): 267-272
Komiyama, K.; Takeshima, H.; Umezawa, I. 1977: Antitumor activity of a new antitumor antibiotic, sporamycin Gan 68(2): 213-219
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Yamamoto, I.; Takahashi, M.; Suzuki, T.; Seino, H.; Mori, H. 1984: Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from Sargassum kjellmanianum Japanese Journal of Experimental Medicine 54(4): 143-151
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Horspool, K.R.; Quarterman, C.P.; Slack, J.A.; Gescher, A.; Stevens, M.F.; Lunt, E. 1989: Metabolism and murine pharmacokinetics of the 8-(N,N-dimethylcarboxamide) analogue of the experimental antitumor drug mitozolomide (NSC353451) Cancer Research 49(18): 5023-5026
Laukaitis, V.A. 1972: Correlation between the structure of sarcolysine derivatives and their antitumor activity and toxicity Voprosy Onkologii 18(9): 83-84
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Morrow, M.; Wait, R.B.; Rosenthal, R.A.; Gamelli, R.L. 1987: Verapamil enhances antitumor activity without increasing myeloid toxicity Surgery 101(1): 63-68
Storozhuk, P.G.; Bykov, I.M.; Malyshev, I.P.; Litvinova, T.N. 1981: Effect of diacarb on the carbonic anhydrase activity in the blood and gastric mucosa and pepsinogen concentration in the gastric mucosa of the rat Biulleten' Eksperimental'noi Biologii i Meditsiny 92(12): 699-701
Niitani, H. 1999: Navelbine (vinorelbine): a review of its antitumor activity and toxicity in clinical studies Gan to Kagaku Ryoho. Cancer and ChemoTherapy 26(10): 1495-1507
Takahashi, K.; Nishikawa, K.; Kita, M.; Nakayama, Y.; Sakakibara, T.; Ito, K.; Tsubosaki, M.; Konoha, N. 1982: Antitumor activity and toxicity of the degradation products and the aquated species of cis-dichlorodiammineplatinum (II) Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(4): 616-623