The influence of albumin degradation products on central action of amphetamine and pentetrazol
Sobaniec, W.; Moniuszko-Jakoniuk, J.; Zarebski, M.; Buczko, W.; Tarasiewicz, S.
Archivum Immunologiae et Therapiae Experimentalis 24(4): 531-536
1976
ISSN/ISBN: 0004-069X PMID: 999469 Document Number: 100140
Trypsin degradation products of albumin given i.p. and into the brain ventricle decreased the psychostimulatory effects of amphetamine as evaluated by Lats test and stereotypy. Albumin degradation products obtained by trypsin and leukocyte digestion increased the convulsant effects of pentetrazol. These effects were possibly connected with a neurohormonal background in the CNS.