Degradation of endo- and exogenous albumin in normal and starved rats
Mal'tsev, G.I.; Vasil'ev, A.V.
Voprosy Meditsinskoi Khimii 38(5): 10-12
1992
ISSN/ISBN: 0042-8809 PMID: 1492384 Document Number: 394527
A rate of degradation of homologous exogenous 14C-albumin proved to be higher 3-fold as compared with that of endogenous 14C-albumin, while the albuminolysis rate was additionally increased in starvation. Evaluation of 14C- and 3H-labels demonstrated that the protein hydrolysis occurred mainly in liver tissue, kidney and intestinal membrane and its rate was elevated in starvation. Dissimilar secretion of exo- and endogenous albumins into small intestine lumen was detected. Removal of albumins was found to depend on augmentation in the proteolytic potential and on reconstructive activity of secondary lysosomes.