Convulsant action of pentetrazol in rats with selective lesions of the hippocampal pyramidal cells with intracerebroventricular kainic acid
Czuczwar, S.J.; Turski, L.; Turski, W.; Kleinrok, Z.
Methods and Findings in Experimental and Clinical Pharmacology 4(5): 293-298
1982
ISSN/ISBN: 0379-0355 PMID: 7121135 Document Number: 195240
Rats were injected uni- or bilaterally with intracerebroventricular kainic acid (0.1 .mu.g/ventricle in 5 .mu.l) and the animals were subsequently challenged with pentetrazol (PTZ) on the 21st day after the administration of the neurotoxin. PTZ was given either s.c. in a single dose of 70 mg/kg or i.v., 1 injection/48 h for 15 trials, in doses of 20 mg/kg to induce kindled seizures. Kainic acid-lesioned animals (especially those injected bilaterally) were more sensitive to the convulsant action of PTZ both in acute and kindled convulsions. The disruption of the hippocampal pyramidal projection to the septum may be responsible for these effects.