Effect of diphynylhydantoin on the histological appearance of internal organs in cat (preliminary study)
Szymańska, K.; Pisarski, W.; Majkowski, J.
Neurologia i Neurochirurgia Polska 10(5): 645-650
1976
ISSN/ISBN: 0028-3843 PMID: 980204 Document Number: 99716
The effects of DPH on internal organs of cats were investigated. The drug (Hydantoinal POLFA) was administered orally in doses 8 to 20 mg/kg daily during from 27 to 560 days. The initial dose was 1.5 mg/kg and it was increased gradually. Consistently occurring changes were found in the liver, kidneys, salivary glands and spleen. In the liver and kidneys the character of changes was mainly degenerative (fatty infiltration of hepatocytes and renal tubular epithelial cells). In the salivary gland the number of mucus-producing cells was increased, in the spleen proliferation of connective tissue and congestion were present.