Studies on the local reactions of the skin to chemical compounds
Renkonen, K.O.; Teir, H.
Annales Medicinae Experimentalis et Biologiae Fenniae 35(1): 67-69
1957
ISSN/ISBN: 0003-4479 PMID: 13444863 Document Number: 9959
Aliphatic alcohols studied cause skin reactions when injected intradermally. The size of the reaction seems to increase with the number of carbon atoms. Butyl and amyl alcohols gave mostly the largest reactions. The weaker reactions caused by hexyl, heptyl and octyl alcohols are supposed to be due to their poor solubilities. Secondary alcohols seem to be somewhat less active than the primary ones, but more active than the tertiary alcohols. So far the rules as similar to the bacteriostatic and bactericidal activities of aliphatic alcohols and to their ability to cause skin reactions in rabbits. Isoamyl alcohol only did not conform to the general rule causing unexpectedly strong skin reactions.
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