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Analysis of the time relationship for the interaction of X-ray induced primary breaks in the formation of dicentric chromosomes

Schmid, E.; Bauchinger, M.; Mergenthaler, W.

International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 30(4): 339-346

1976

ISSN/ISBN: 0020-7616
PMID: 1086845
Document Number: 99392
In split-dose experiments, the time relationship for the interaction of primary breaks in the formation of dicentric chromosomes was analysed. Human peripheral lymphocytes were irradiated with a dose of 340 R of 220 kV X-rays split into two equal fractions separated by intervals up to 360 min. Assuming an exponential decline of the time-dependent quadratic component of the dose realtion of dicentrics a theoretical formula was deduced. Fitting this formula to the empirical data a mean time of 110 min could be calculated in which primary breaks induced by both dose-fractions can interact to form dicentric chromosomes.

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