Stabilization of microtubules by lithium ion
Bhattacharyya, B.; Wolff, J.
Biochemical and Biophysical Research Communications 73(2): 383-390
1976
ISSN/ISBN: 0006-291X PMID: 826253 Document Number: 98782
Li+, in concentrations of 0.2-1.0 mM, promotes tubulin polymerization, provided small concentrations of Mg2+ are present. This effect of Li on polymerization, at suboptimal concentration of Mg, is additive for the 2 metal ions. Both Li+ and Mg2+ protect microtubules against the depolymerizing effects of colchicine or vinblastine.
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