The effect of angiotensin II on electrolyte excretion by the renal tubules
Melton, L.B.; Frazier, L.W.
Texas Reports on Biology and Medicine 34(2-4): 289-295
1976
ISSN/ISBN: 0040-4675 PMID: 1030540 Document Number: 98768
In vivo studies were done on mongrel dogs to determine the effect of angiotensin II on renal electrolyte excretion. Angiotensin II was infused directly into the left renal artery at a rate of 1 ng/kg per min. Angiotensin produced consistent reductions in the excretion of Na+, K+ and Cl- in the left kidney. These reductions could not be attributed to decreases in GFR . Electrolyte excretion by the right kidney was constant. These data are consistent with the hypothesis that angiotensin II may function as an intrarenal, antinatriuretic hormone.