Discriminable effects of benzodiazepines
Overton, D.A.
Psychopharmacology Communications 2(4): 339-343
1976
ISSN/ISBN: 0098-616X PMID: 11529 Document Number: 98635
In a shock-escape T-maze task, rats rapidly discriminated diazepam, flurazepam and chloridazepoxide from no drug. The discriminable effects of these benzodiazepines were not completely interchangeable with those of barbiturate anesthetics. The dose-response curve for diazepam asymptoted over the range 15 to 100 mg/kg, ip whereas dose-response curves for flurazepam and chloridazepoxide were more linear.