Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters
Johnson, M.K.
Federation Proceedings 35(1): 73-74
1976
ISSN/ISBN: 0014-9446 PMID: 1245234 Document Number: 97645
Delayed neurotoxic effects arise as a result of two distinct biochemical events: 1) inhibiton of neurotoxic esterase, and 2) 'aging' of inhibited enzyme. Protective agents undergo reaction 1 but cannot undergo 2. Reaction 2 may interfere with a normal physiological control mechanism.
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