Pregnancy type nephropathies experimentally induced in rats
Coquoin-Carnot, M.; Engelmann, F.; Engelmann, P.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction 5(6): 749-756
1976
ISSN/ISBN: 0368-2315 PMID: 1036105 Document Number: 97157
The theory behind our work is the following: toxaemia may be due to the accidental passage of fetal proteins into the maternal organism. Particularly suspect are alpha-fetoproteins from the fetal blood or the amniotic fluid. The experiments were carried out on rats by injecting amniotic fluid or fetal serum into the rats by different routes and rhythms and in different doses. Arterial blood pressure readings showed that the levels were consistently higher than those of controls. The study of the kidneys anatomo-pathologically shows the following triad: intense congestion, tubular lesions, connective tissues affected. These lesions are reversible. The discussion concentrates on the similarities and differences between these findings and pathological changes found in kidneys in pregnancy.