Insulin receptors: physiopathological implications and applications
Freychet, P.
Annales de Biologie Clinique 34(5): 365-370
1976
ISSN/ISBN: 0003-3898 PMID: 1015674 Document Number: 96665
The study of insulin receptors has permitted important progress in the knowledge of various pathological conditions, such as, diabetes, obesity. Studies in recent years of the changes in the link between insulin and receptors has proved that the receptor may present interesting variations in affinity with regard to insulin. The notion of negative cooperativity is thus discussed by the lecturer. The number of receptors may also vary. A study of insulin receptors in the experimental, genetic or acquired obesity and in human obesity, is very instructive. Another point emphasized concerns the use of the receptor for the study of structure activity relationships, but also the possibility of estimation of insulin according to the principle of radiocompetition by the receptor. This method of analysis permits one to study the various forms of hormone in patients.