Current concepts of the physiopathology of coronary beta-adrenergic receptors, and their clinical applications
Barbato, E.; Wijns, W.; De Bruyne, B.; Mascia, G.; Piscione, F.
Recenti Progressi in Medicina 96(9): 411-415
2005
ISSN/ISBN: 0034-1193 PMID: 16229320 Document Number: 591433
Beta-adrenergic vasodilation plays a key role in the regulation of coronary blood flow, in particular during sympathetic nervous system activation. Beta1-adrenergic receptors are mostly represented in epicardial coronary vessel, while beta2 receptors are located in microvasculature. Coronary atherosclerosis is associated with a significant impairment of beta-adrenergic receptor response. This might contribute to precipitate myocardial ischemia.