Insulin receptors and mechanism of action of insulin and of insulin-like growth factors
De Meyts, P.
Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 149(3-4) 181-190; Discussion: 190-194
1994
ISSN/ISBN: 0377-8231 PMID: 7841929 Document Number: 438745
A novel mechanism of activation of the insulin and IGF-I receptors by their respective ligands is proposed, whereby the bivalent ligand bridges the two receptor alpha subunits at opposite sites in a symmetrical receptor structure. The proposed mechanism accounts for the binding stoichiometry and the phenomenon of negative cooperativity. It may play an important role in the regulation of mitogenesis.
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