Benzodiazepines and reproduction of swiss-webster mice
Guerriero, F.J.; Fox, K.A.
Research Communications in Chemical Pathology and Pharmacology 13(4): 601-610
1976
ISSN/ISBN: 0034-5164 PMID: 4863 Document Number: 96545
Chronic dietary administration of 6 different benzodiazepine tranquilizers (chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, and nitrazepam) to breeding pairs of Swiss-Webster mice resulted in alterations of the normal patterns of reproductive behavior and fetal growth. Significant decreases in mating performance were seen among mice given diets containing 0.15% chlordiazepoxide, 0.05% diazepam, 0.05 and 0.15% oxazepam, 0.02 and 0.10% prazepam, 0.10% flurazepam, and 0.025% nitrazepam. Offspring in all drug treatments showed significantly depressed body weights at birth.