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Structural and functional changes in myosin in chronic coronary insufficiency

Davydova, S.M.; Kalamkarova, M.B.; Kolesova, O.E.; Podlubnaia, Z.A.; Chechulin, I.S.

Biofizika 21(2): 295-299

1976

ISSN/ISBN: 0006-3029
PMID: 131586
Document Number: 96422
A study of myosin extracted from dog's cardiac muscle at different stages of chronic heart failure (from 1 week to 1 year) was carried out. A decrease of UV-luminescence intensity, flow birefringence and ATPase activity (to 70%) was observed. The electron microscopic investigation of myosin and LMM structure shows the loss of ability to form typical paracrystals by LMM, the electron microscopic appearance of the whole myosin being unchanged.

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