The influence of thyrotrophin-releasing hormone (TRH) on depression in the alcohol withdrawal syndrome
Loosen, P.T.; Wilson, I.C.; Lara, P.P.; Prange, A.J.; Pettus, C.
Arzneimittel-Forschung 26(6): 1164-1166
1976
ISSN/ISBN: 0004-4172 PMID: 822858 Document Number: 96348
A single injection of thyrotrophin-releasing hormone (TRH) was compared to injection of nicotinic acid or saline in alcohol withdrawal syndrome. An antidepressant action of TRH was demonstrated on injection day. Thereafter there were no reliable differences between treatment groups, perhaps due to rapid spontaneous remission in all groups. Two of five patients who received TRH showed a grossly subnormal TSH response.
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