The effect of thyrotrophin releasing hormone versus placebo in combination with basic imipramine therapy of depressive patients
Benkert, O.; Lücke, K.H.
Arzneimittel-Forschung 26(6): 1162-1164
1976
ISSN/ISBN: 0004-4172 PMID: 822857 Document Number: 103000
20 female and 10 male patients with a retarded-depressive syndrome received imipramine (3 X 50 mg/day) for 20 days. In a double blind study oral thyrotrophin releasing hormone (TRH) (2 X 40 mg/day) and placebo, respectively, were added for the first 2 weeks. The patients were rated with the Hamiltion-depression scale and a selfrating depression scale. But the statistical evaluation showed no difference between the imipramine/TRH and the imipramine/placebo group.
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