Changes in plasma glucose and lactate concentrations and enzyme activities in the neonatal calf with diarrhea
Lewis, L.D.; Phillips, R.W.; Elliott, C.D.
American Journal of Veterinary Research 36(4 Part 1): 413-416
1975
ISSN/ISBN: 0002-9645 PMID: 1124876 Document Number: 95799
Plasma glucose and lactate concentrations and glutamate-pyruvate transaminase (SGPT), glutamate-oxalacetic transaminase (SGOT), alkaline phosphatase (AP), aldolase (ALD), creatine phosphokinase (CPK), and hydroxybutyrate dehydrogenase (HBD) activities were determined before, throughout the incubation period, and during the course of a virus-induced diarrhoea in the neonatal calf. Hypoglycaemia with a glucose concentration less than 40 mg/dl of plasma was observed in three of ten calves. Plasma lactate concentration increased to nearly twice normal in seven and 6-7 times normal in two of the animals. The major change in both glucose and lactate concentrations during diarrhoea occurred during the 24 hours preceding death. Changes in SGPT, SGOT, or AP activities were not observed indicating the absence of marked hepatic damage. The ALD, CPK and HBD activities were increased in two calves and the CPK alone was increased in two others, indicating cardiac and possibly skeletal muscle damage.