Paraprotein and Beta 2 -Microglobulin Analyses in Multiple Myeloma -Do we Need to Monitor both?
Sinclair, D.; Cranfield, T. and Mary Ganczakowski
Clinical Laboratory 49(3-4): 129-134
2003
ISSN/ISBN: 1433-6510 PMID: 12705694 Document Number: 9551
The relationship between serum paraprotein and beta2-microglobulin (B2m) levels was studied in serial samples from 41 patients with myeloma. A positive correlation coefficient was found in 70.7% of myeloma patients indicating that no extra information was gained from measuring both analytes routinely. As a result, the workload for B2m fell without any diminution in clinical service.
Document emailed within 1 workday
Related Documents
Singhal, S.; Powles, R.; Milan, S.; Raje, N.; Viner, C.; Treleaven, J.; Raymond, J.; Cunningham, D.; Mehta, J. 1995: Kinetics of paraprotein clearance after autografting for multiple myeloma Bone Marrow Transplantation 16(4): 537-540Scudla, V.; Vavrdová, V.; Budíková, M.; Indrák, K. 1991: Clinical significance of correction of serum beta 2-microglobulin levels for serum creatinine in multiple myeloma Acta Universitatis Palackianae Olomucensis Facultatis Medicae 131: 257-264
Bettini, R.; Redaelli, S.; Maino, C.; Bertuol, S.; Costantini, C.; Lazzarini, A.; Brivio, L.; Gorini, M. 2005: Prognostic value of serum beta2-microglobulin in multiple myeloma Recenti Progressi in Medicina 96(2): 81-86
Bataille, R.; Grenier, J. 1986: Role of the assay of serum beta 2 microglobulin in the clinical evaluation of myeloma Presse Medicale 15(34): 1723-1725
Kraj, M.; Maj, S.; Pogłód, R.; Rostkowska, J. 1989: Clinical usefulness of serum beta2-microglobulin determination in patients with multiple myeloma Acta Haematologica Polonica 20(2): 140-151
Kay, T.W.; Parker, J.L.; Stephens, L.A.; Thomas, H.E.; Allison, J. 1996: RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice Journal of Immunology 157(8): 3688-3693
Alsobhi, E.M.; Hashim, I.A.; Abdelaal, M.A.; Aljifri, A.M.; Alshamy, A.M. 2007: Elevated cerebrospinal fluid beta-2 microglobulin as a tumor marker in a patient with myeloma of the central nervous system Saudi Medical Journal 28(1): 128-130
Wang, Z.; Hu, X.Z.; Tatake, R.J.; Yang, S.Y.; Zeff, R.A.; Ferrone, S. 1993: Differential effect of human and mouse beta 2-microglobulin on the induction and the antigenic profile of endogenous HLA-A and -B antigens synthesized by beta 2-microglobulin gene-null FO-1 melanoma cells Cancer Research 53(18): 4303-4309
Revillard, J.P.; Vincent, C.; Clot, J.; Sany, J. 1982: Beta 2-Microglobulin and beta 2-microglobulin-binding proteins in inflammatory diseases European Journal of Rheumatology and Inflammation 5(4): 398-405
Yelin, C.A.; Rojman, J.A. 1972: Light chain disease or myeloma with Bence Jones paraprotein Prensa Medica Argentina 59(15): 572-574
Itoh, Y.; Enomoto, H.; Takagi, K.; Kawai, T.; Suzuki, M.; Yamanaka, T.; Abe, C. 1982: A comparative study of serum alpha 1-microglobulin and beta 2-microglobulin levels in various disorders Rinsho Byori. Japanese Journal of Clinical Pathology 30(10): 1118-1121
Itoh, Y. 1998: Urinary alpha 1-microglobulin and beta 2-microglobulin in diabetes mellitus Nihon Rinsho. Japanese Journal of Clinical Medicine 56(Suppl 3): 303-306
Weber, D.M. 2003: Strategies in treating newly diagnosed or untreated multiple myeloma patients. from the Multiple Myeloma Research Foundation Oncology 17(6): 765-767
Hotta, O.; Yusa, N.; Mukaiyama, I.; Taguma, Y. 1999: Usefulness of serum cystatin-C as a marker of the renal function: a comparative evaluation with beta 2-microglobulin, alpha 1-microglobulin and creatinine Nihon Jinzo Gakkai Shi 41(8): 797-803
Liberati, A.M.; Cinieri, S.; Senatore, M.G.; Portuesi, M.G.; De Angelis, V.; Di Clemente, F.; Schippa, M.; Ferrajoli, A.; Arzano, S.; Berruto, P. 1990: Phase I-Ii trial on natural beta interferon in chemoresistant and relapsing multiple myeloma Haematologica 75(5): 436-442
Itoh, Y. 2002: Alpha 1-microglobulin, beta 2-microglobulin Nihon Rinsho. Japanese Journal of Clinical Medicine 60(Suppl 8): 556-560
Hei, Z.-q.; Li, X.-y.; Shen, N.; Pang, H.-y.; Zhou, S.-l.; Guan, J.-q. 2008: Prognostic values of serum cystatin C and beta2 microglobulin, urinary beta2 microglobulin and N-acetyl-beta-D-glucosaminidase in early acute renal failure after liver transplantation Chinese Medical Journal 121(14): 1251-1256
Pasqualetti, P.; Casale, R.; Collacciani, A.; Colantonio, D. 1989: Evaluation of a morphologic staging method (myeloma progression score) in multiple myeloma Medicina 9(3): 280-282
Barlogie, B.; Alexanian, R. 1989: Second International Workshop on Myeloma: advances in biology and therapy of multiple myeloma Cancer Research 49(24 Pt 1): 7172-7175
Wu, M-Jei.; Fang, H-Chang.; Chang, T-Yuan.; Lo, Y-Shing.; Chung, H-Min. 2002: Multiple myeloma with myeloma nephropathy in a patient with Hashimoto's thyroiditis Journal of the Formosan Medical Association 101(6): 421-424