Elevated cerebrospinal fluid beta-2 microglobulin as a tumor marker in a patient with myeloma of the central nervous system
Alsobhi, E.M.; Hashim, I.A.; Abdelaal, M.A.; Aljifri, A.M.; Alshamy, A.M.
Saudi Medical Journal 28(1): 128-130
2007
ISSN/ISBN: 0379-5284 PMID: 17206305 Document Number: 611692
Myeloma involvement of the nervous system is rare. Extensive literature review revealed only a few cases reported from different parts of the world. The presence of CNS symptoms and detection of plasma cells in the CSF is the usual basis of diagnosis. In addition, immunoelectrophoresis and immunofixation for detection of monoclonal protein confirm the diagnosis in some cases, while some authors used flow cytometry and cytogenetic studies on CSF. Reports of multiple myeloma also include unfavorable cyrogenetic abnormalities of chromosome 13. We report a case with relapsed CNS multiple myeloma with the detection of elevated beta-2 microglobulin (beta 2M) as a tumor marker in the CSF.