Immunosuppression effected by macrophage surfaces
Ptak, W.; Gershon, R.K.
Journal of Immunology 115(5): 1346-1350
1975
ISSN/ISBN: 0022-1767 PMID: 809511 Document Number: 95423
Heat-killed macrophages (but not six other types of cells tested) suppress Mishell-Dutton cultures by a mechanism that does not adversely affect cell viability. The suppressive effect is abolished by treatments that inactivate receptors for cytophilic antibody. We suggest macrophages may absorb, and thus render inoperative, factors which are necessary for lymphocyte cooperation.
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