Expansion of plasma volume effected by 5, 20, and 25 per cent albumin solution
Lamke, L.O.; Liljedahl, S.O.
Lakartidningen 74(15): 1483-1485
1977
ISSN/ISBN: 0023-7205 PMID: 846269 Document Number: 4122
Fifty grams of albumin were infused in the immediate post-operative period as either 5, 20 or 25 per cent solutions. With all three solutions the increase in plasma volume was 500 ml or 11 ml per gram retained albumin, which is less than the normal water-binding capacity of albumin found in in-vitro studies and in some clinical studies. This may be explained by a blocking of the water-binding capacity of the albumin, or by the action of other unknown mechanisms, when albuniin is given in an amount exceeding the losses. The expansion of the plasma volume did not depend on the concentration of the solutions administered, but only on the amount of albumin given and the deficit in plasma volume. Since albumin is a good plasma expander and a drug with few secondary effects it is recommended in the treatment of shock. The authors prefer the 5 % solution which contains an electrolyte solution and is more easily infused, because of its low viscosity
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