Osseous hyperelongation of the tibia of the rabbit during the period of growth caused by injection, into the soft parts of the proximal metaphysial region of the leg, of an irritating solution (formalin) . (Experimental research)
Calati, A.
Archivio di Ortopedia 73: 923-928
1960
ISSN/ISBN: 0004-0118 PMID: 13689890 Document Number: 9515
Continuing a series of preceding researches performed in order to throw some light on the bone hyperelongation which is often observed in young subjects during growth in different clinical and experimental situations (following: fractures, acute osteomyelitis, tbc gonylitis, periostal removal according to Oilier, closing of the medullary canal according to Trueta, fractures of the adjacent peroneum according to Calati etc.). The A. investigates whether even amicrobic inflammatory conditions following the subcutaneous injection of an irritating solution near one metaphysis may elicit a hyperstimulation of the boneforming activity of the adjacent fertile cartilage and thus a lengthening of the bone. Actually, the injection of 2 mm2 of a 40% formaline solution in the subcutaneous tissue of the submetaphysary region of young rabbits' legs, causes a hyperlengthening of the tibia on the side treated, which varies between 2,5 and 0,5 mm. No such reaction has been observed in the femur. The A. believes that the result of the experiment is in accordance with his own views, considering this reaction present in different clinical and experimental conditions as due to the « general adaptation syndrome» by Selye.
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