Production of the methyl ether of 8,14-seco-delta,3,5,(10),9(11)-estratetraendiol-3,17beta-one-14 using a culture of Saccharomyces cerevisiae BKMU-488

Gulaia, V.E.; Kriutchenko, E.G.; Ratél', N.N.; Messinova, O.V.; Ananchenko, S.N.; Gulaia, V.E; Kriutchenko, E.G; Ratél&apo; , N.N; Messinova, O.V; Ananchenko, S.N

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Production of the methyl ether of 8,14-seco-delta,3,5, (10) ,9 (11) -estratetraendiol-3,17beta-one-14 using a culture of Saccharomyces cerevisiae BKMU-488

Gulaia, V.E.; Kriutchenko, E.G.; Ratél', N.N.; Messinova, O.V.; Ananchenko, S.N.

Prikladnaia Biokhimiia i Mikrobiologiia 11(5): 657-661

1975

ISSN/ISBN: 0555-1099

PMID: 1103120

Document Number: 94558

The culture Saccharomyces cerevisiae BKMU-499 was selected from 100 strains of different Saccharomyces species to obtain an optically active methyl ester 8,14-seco-delta1,3,5(10),9(11)-estratetraendiol-3-17beta-on-14. Various conditions of the transformation were examined. The yield of this keto-alcohol depended on the following factors: level of aeration, method of steroid administration, physiological state of the culture, and composition of the cultivation medium. The optimal yeild of the optically active product was 84%.