Methylethylketone Poisoning in the Dog
Verstraete, A.; Vanderstock, J.; Mattheeuws, D.
Verhandelingen - Koninklijke Vlaamse Academie Voor Geneeskunde van Belgie 26: 71-84
1964
ISSN/ISBN: 0300-9017 PMID: 14126619 Document Number: 9358
The first part of this report describes a case of butanon intoxication in a dog. Besides vomiting, muscular debility and emaciation, the most marked symptom was the formation of masses of ammoniomagnesium phosphate cristals in the urine. They disappeared when the dog stayed no longer in the contaminated air, but reappeared as soon as butanon vapours were again inhaled. The same phenomenon has been observed in 5 further laboratorium dogs. The presence of ketone bodies in the urine could, however, not been evidenced by the sodiumnitroprussiate reaction. The urine has been daily probed in this dogs and without delay, the magnesium, calcium, phosphor and ammonium levels have been determined as also the quantity of free acides by means of titration with NaOH. Under the influence of butanon, the ammonium level and the quantity of free acides has increased. This increase was accompanied by cristallisation of the triple phosphate. The authors presume that this increase of the quantity of free acides results of the methylethylketone intoxication; the increase of the degree of acidity could thus be compensated by an enhanced excretion of the ammonium by the kidneys, which may give rise to the tendency of precipitation of the ammoniomagnesium phosphate cristals. In three further laboratorium dogs, cristals could not be detected in the urine after butanon intoxication and the ammonium level was not obviously increased. Only the phosphor concentration showed a descending tendency. We could probably succeed here to balance the physiological pH by a decrease in the excretion of phosphate. The autors presume also that the difference in the reaction by both series of dogs could have a dietary cause. Indeed, the dogs nourished especially with meat and bread give readily a cristallisation in the urine, while those nourished with milk and bread, did not present this phenomenon and responded in the same way as the second series of laboratorium dogs.
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