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Effect of ethyl 2-cyanoacrylate adhesive on rabbit vaginal mucous membrane

Harikrishnan, P.; Murthy, P.S.

Indian Journal of Experimental Biology 32(10): 759-760

1994

ISSN/ISBN: 0019-5189
PMID: 7821988
Document Number: 934
The safety of an ethyl 2-cyanoacrylate-containing instant adhesive for orthodontic use was investigated employing rabbit mucous membrane irritancy test. Inflammatory changes which did not exceed an average score of 2+ were observed in 66% of animals 72 hr after a single intravaginal application of the adhesive (10+-3 mg/rabbit). Persistent histopathological changes were observed in 2 out of 6 rabbits 15 days post-application of the adhesive. The results suggest that ethyl 2-cyanoacrylate may not be a primary irritant but nevertheless be employed with caution.

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Effect of ethyl 2-cyanoacrylate adhesive on rabbit vaginal mucous membrane

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