Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effects of exposure of neonatal mice to 17beta-estradiol on subsequent age-incidence and morphology of carcinogen-induced mammary dysplasia

Warner, M.R.; Warner, R.L.

Journal of the National Cancer Institute 55(2): 289-298

1975

ISSN/ISBN: 0027-8874
PMID: 808639
Document Number: 93397
Mice exposed to estrogens as neonates developed more mammary dysplasias and had different morphologic types of dysplasias than did normal animals when both groups were exposed to a carcinogen: 1) before puberty, 2) during active mammary growth, 3) or at 6 months of age (the time when spontaneous dysplasias begin to appear in normal animals). The relative percentages of various morphologic types of dysplasias differed in hosts that received different treatments. The significance for subsequent patterns of mammary disease caused by exposure of neonates to 17beta-estradiol was discussed.

Document emailed within 1 workday
Secure & encrypted payments

Hayashi, S.; Nagasawa, H. 1977: Inhibition by neonatal hypothalamic estrogen implantation of carcinogen-induced mammary tumorigenesis in female rats Gan 68(2): 139-143
Ponder, B.A.; Wilkinson, M.M. 1986: Direct examination of the clonality of carcinogen-induced colonic epithelial dysplasia in chimeric mice Journal of the National Cancer Institute 77(4): 967-976
Lahiri, T.; Banerjee, M. 1986: Differential responses of carcinogen-induced fibrosarcoma of mice to altered regimes of cold exposure Neoplasma 33(3): 307-312
De Launoit, Y.; Kiss, R.; Paridaens, R.; Danguy, A.; Pasteels, J.L. 1987: Effect of estradiol -17- beta (E2) on cell proliferation in the uterus and the MXT mammary tumor borne by intact, ovariectomized and/or hypophysectomized mice In Vivo 1(3): 173-179
Nagasawa, H.; Yanai, R.; Taniguchi, H. 1976: Importance of mammary gland DNA synthesis on carcinogen-induced mammary tumorigenesis in rats Cancer Research 36(7 Part 1): 2223-2226
Kledzik, G.S.; Bradley, C.J.; Marshall, S.; Campbell, G.A.; Meites, J. 1976: Effects of high hoses of estrogen on prolactin-binding activity and growth of carcinogen-induced mammary cancers in rats Cancer Research 36(9 Pt.1): 3265-3268
Anisimov, V.N.; Sheiko, E.V. 1996: Skin carcinogenesis induced be neonatal administration of 5-bromo-2'-deoxyuridine and subsequent treatment with 12-O-tetradecanoylphorbol-13-acetate in mice Voprosy Onkologii 42(1): 82-84
Guzman, R.C.; Osborn, R.C.; Swanson, S.M.; Sakthivel, R.; Hwang, S.I.; Miyamoto, S.; Nandi, S. 1992: Incidence of c-Ki-ras activation in N-methyl-N-nitrosourea-induced mammary carcinomas in pituitary-isografted mice Cancer Research 52(20): 5732-5737
Swanson, S.M.; Christov, K. 2003: Estradiol and progesterone can prevent rat mammary cancer when administered concomitantly with carcinogen but do not modify surviving tumor histology, estrogen receptor alpha status or Ha-ras mutation frequency Anticancer Research 23(4): 3207-3213
Bourtourault, M.; El Hiyani, L.; Gayet, G.; Samperez, S.; Jouan, P. 1984: Inhibitory effects of Celiptium on thymidine kinase synthesis induced in the uterus by 17 beta-estradiol Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 178(5): 499-505
Sylvester, P.W.; Aylsworth, C.F.; Van Vugt, D.A.; Meites, J. 1982: Influence of underfeeding during the "critical period" or thereafter on carcinogen-induced mammary tumors in rats Cancer Research 42(12): 4943-4947
Lareef, M.H.; Garber, J.; Russo, P.A.; Russo, I.H.; Heulings, R.; Russo, J. 2005: The estrogen antagonist ICI-182-780 does not inhibit the transformation phenotypes induced by 17-beta-estradiol and 4-OH estradiol in human breast epithelial cells International Journal of Oncology 26(2): 423-429
Chen, H.J.; Bradley, C.J.; Meites, J. 1977: Stimulation of growth of carcinogen-induced mammary cancers in rats by thyrotropin-releasing hormone Cancer Research 37(1): 64-66
Mehta, R.G.; Steele, V.; Kelloff, G.J.; Moon, R.C. 1991: Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro Anticancer Research 11(2): 587-591
Yuri, T.; Nikaido, Y.; Shimano, N.; Uehara, N.; Shikata, N.; Tsubura, A. 2004: Effects of prepubertal zeranol exposure on estrogen target organs and N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats In Vivo 18(6): 755-761
Luttge, W.G.; Jasper, T.W.; Gray, H.E.; Sheets, C.S. 1977: Estrogen-induced sexual receptivity and localization of 3H-estradiol in brains of female mice: effects of 5 alpha-reduced androgens, progestins and cyproterone acetate Pharmacology Biochemistry and Behavior 6(5): 521-528
Hasegawa, R.; Kimura, J.; Yaono, M.; Takahashi, S.; Kato, T.; Futakuchi, M.; Fukutake, M.; Fukutome, K.; Wakabayashi, K.; Sugimura, T. 1995: Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats Cancer Research 55(19): 4333-4338
Narasimhan, T.R.; Safe, S.; Williams, H.J.; Scott, A.I. 1991: Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced glucose metabolism in MCF-7 human breast cancer cells: 13C nuclear magnetic resonance spectroscopy studies Molecular Pharmacology 40(6): 1029-1035
Nagasawa, H.; Yanai, R. 1974: Frequency of mammary cell division in relation to age: its significance in the induction of mammary tumors by carcinogen in rats Journal of the National Cancer Institute 52(2): 609-610
Nagasawa, H.; Yanai, R.; Shiota, K.; Nakajima, Y. 1980: Lack of relationship between prolactin binding and growth rate of carcinogen-induced mammary tumors or circulating levels of mammotropic hormones in rats Gan 71(2): 271-272