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Inhibitory effects of Celiptium on thymidine kinase synthesis induced in the uterus by 17 beta-estradiol

Bourtourault, M.; El Hiyani, L.; Gayet, G.; Samperez, S.; Jouan, P.

Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 178(5): 499-505

1984

ISSN/ISBN: 0037-9026
PMID: 6241022
Document Number: 223600
Inhibitory effects of Celiptium on the thymidine kinase synthesis induced by oestradiol-17 beta in the rat uterus. In the rat uterus, the synthesis of thymidine kinase specifically induced by oestradiol-17 beta was inhibited by Celiptium. The synthesis was totally inhibited when the drug was administered before the oestrogen and partially when it was administered after. These facts suggested that Celiptium was competitive to the acceptor sites for oestradiol-receptors and inhibited the expression of the thymidine kinase gene.

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