Irbesartan-associated persistent edema of the eyelids, face, and neck
Cohen, P.R.
Journal of Drugs in Dermatology Jdd 1(3): 329-330
2002
ISSN/ISBN: 1545-9616 PMID: 12851994 Document Number: 9228
Irbesartan, an angiotensin II receptor antagonist (AIIRA), is an antihypertensive agent that inhibits the activity of angiotensin II by selectively binding to angiotensin II type 1 (AT1) receptors. The new onset of sustained periorbital, facial, and neck edema following the initiation of irbesartan therapy is described in a hypertensive 52-year-old woman. The patient's edema was not life threatening, remained unchanged following discontinuation of the medication, and persisted when treatment with the drug was subsequently reinstituted. Facial edema is a very uncommon adverse event that may occur in patients receiving irbesartan.
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