Liver tumors in women on contraceptive steroids
Christopherson, W.M.; Mays, E.T.; Barrows, G.H.
Obstetrics and Gynecology 46(2): 221-223
1975
ISSN/ISBN: 0029-7844 PMID: 168523 Document Number: 92060
The possible association between oral contraceptives and benign liver tumors has recently been reported. To date the majority of cases have been diagnosed as benign hepatomas (liver cell adenomas). We have had the opportunity to study 13 such cases. Eight have been examples of focal nodular hyperplasia of the liver; however, in addition, there were examples of hepatocellular carcinoma, liver cell adenoma, and possible liver cell hamartoma; all were in women on "the pill." Gynecologists are alerted to the fact that many of the patients present with symptoms of acute abdomen, syncope or shock, and intrahepatic or intraperitoneal bleeding. Prompt diagnosis and treatment may be lifesaving.
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