Effect of eltroxine and neomercazol on monoamine oxidase from rat tissues
Kaul, P.; Srinivasan, S.; Udupa, K.N.
Indian Journal of Physiology and Pharmacology 19(2): 65-70
1975
ISSN/ISBN: 0019-5499 PMID: 1158431 Document Number: 91146
The paper describes the effect of two drugs, (Eltroxine and Neomercazol) on the nature and activity of monoamine oxidase (MAO) in albino rats. Four organs namely liver, kidney, brain and heart were examined from this point of view. Biological activity measurements were done using tyramine hydrochloride as the substrate. The liver MAO from normal as well as the drug treated rats were subjected to DEAE gel filtration studies. These investigations show that there is a significant difference in the biological activity as well as in the actual nature of the enzyme as a result of treatment with the drugs mentioned above.