Ontogenesis of monoamine oxidase and catechol-O-methyl transferase in various tissues of domestic swine
Stanton, H.C.; Cornejeo, R.A.; Mersmann, H.J.; Brown, L.J.; Mueller, R.L.
Archives Internationales de Pharmacodynamie et de Therapie 213(1): 128-144
1975
ISSN/ISBN: 0003-9780 PMID: 1156012 Document Number: 89331
Activities of monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT) in liver, kidney, heart, spleen, hindbrain and adrenal glands were compared in adult dogs, cats, guinea-pigs, rabbits, rats, sheep and 150-day-old swine. Swine had the highest COMT activity and dogs and cats the lowest, in most tissues. MAO was more variable. The ontogenesis of MAO and COMT was evaluated in the same 6 tissues of swine from 10 days before birth to 150 days of age. COMT and MAO generally increased with age in kidney and liver. COMT increased in heart, spleen, and adrenals until 14 days of age, decreased in spleen and adrenals until 150 days, but remained elevated in heart. Brain MAO activities were near or above 150-day-old levels at birth and changed little with age. Heart MAO fell from birth to 70 days of age, while spleen and adrenal activities increased with age.