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A competitive radioisotope binding technic for the determination of prednisolone and of a new synthetic corticoid

Leclercq, R.; Copinschi, G.

Pathologie-Biologie 23(10): 913-915

1975

ISSN/ISBN: 0369-8114
PMID: 772542
Document Number: 90198
A competitive protein binding technique for the determination of plasma prednisolone in dexamethasone-treated men was found suitable for the estimation of plasma levels of a new non-steroidal compound having a chemical structure related to that of prednisolone. The method used allowed us to determine the time of appearance of this compound in the peripheral plasma after oral administration, the time of the peak and the apparent disappearance half-life which were comparable to that of prednisolone.

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