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Effect of cytostatic drugs on nucleic acid synthesis in mouse thymocytes and chick embryo cells

Håkansson, L.

Arzneimittel-Forschung 25(3): 378-382

1975

ISSN/ISBN: 0004-4172
PMID: 1080422
Document Number: 90040
Cell suspensions of either mouse thymocytes or chick embryo cells were incubated with labelled precursors after preincubation with different cytostatic drugs. The total time of in vitro incubation was four hours. The ratio between the amount of incorporated labelled precursors and the total amount of DNA was determined and used to measure the cytostatic effect. All drugs used caused a marked depression of this ratio. The cytostatic drugs had no effect on the phosphorylation of thymidine.

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