Effect of the degree of hypothermia on the intensity of DNA, RNA and protein synthesis in a tumor and in normal tissue
Diuskaliev, Z.D.; Karakulov, R.K.
Voprosy Onkologii 21(3): 60-65
1975
ISSN/ISBN: 0507-3758 PMID: 1130021 Document Number: 88389
In rats were Heren carcinoma at the initial stage of hypothermia (30-31 degrees C) in hepatic tissues there was observed at a greater intensity of protein and nucleic acids synthesis contrary to its marked reduction in tumor tissues. In tumor tissues a cessation of protein synthesis was observed at 20-21 degrees C. while that of nucleic acids at 14-15 degrees C. Under these regimens of hypothermia no complete cessation of protein and nucleic acids synthesis in hepatic tissue occurred. However, their synthesis was markedly suppressed.