Effects of potassium perchlorate on thyroid uptake of i 131 in rats

Campanacci, L.; Fabbrini, A.; Menzinger, G.

Rassegna di Fisiopatologia Clinica e Terapeutica 30(1): 19-30

1958


ISSN/ISBN: 0033-9520
PMID: 13542823
Document Number: 8812
The thyroid uptake of 131I was studied in the rat after prolonged treatment by potassium perchlorate. The procedure used in this research included the determination of the radioactivity of the rat thyroid glands by means of a scintillation counter, the current histological techniques and the autohistoradiographic method. The results were compared with those obtained in control animals and in animals treated by methyl-thiouracil and by methyl-thiouracil associated with potassium perchlorate. The action of potassium perchlorate consists of (a) reduced thyroid uptake of iodides, and (b) hypertrophy of the glandular epithelium, considerably less marked than the hypertrophy induced by methyl-thiouracil. The foregoing effects of potassium perchlorate are enhanced to a considerable extent by the simultaneous administration of methyl-thiouracil.

Document emailed within 1 workday
Secure & encrypted payments

Effects of potassium perchlorate on thyroid uptake of i 131 in rats