Effects of pyrethroids on the glutamate uptake system in synaptic vesicle of rats
Wu, J.; Xia, R.; Shi, N.; Liu, Y.
Wei Sheng Yan Jiu 28(5): 261-262
1999
ISSN/ISBN: 1000-8020 PMID: 12712690 Document Number: 503362
In order to study the effects of cypermethrin and permethrin insecticides on the glutamate uptake of rat brain, brain synaptic vesicles and cypermethrin or permethrin were incubated with 3H-glutamate (37 KBq, 1 mumol/L). The radio activity was detected by a liquid scintillation counter. The results showed that cypermethrin and permethrin in the concentration of 10(-9)-10(-4) mol/L could inhibit the high affinity uptake of glutamate in the synaptosomes of cerebral cortex, hippocampus and striatum in a dose-response manner. Cypermethrin was more powerful than permethrin at the same dose. It was concluded that glutamate uptake inhibition might play a vital role in the neurotoxicity induced by pyrethroid insecticides.