Mastocytoma cell migration in vitro: inhibition by MIF-containing supernatants

Cohen, M.C.; Zeschke, R.; Bigazzi, P.E.; Yoshida, T.; Cohen, S.

Journal of Immunology 114(5): 1641-1643

1975


ISSN/ISBN: 0022-1767
PMID: 164509
Document Number: 87961
Supernatants with macrophage migration inhibition factor (MIF) activity were obtained from cultures of antigen-stimulated guinea pig and human lymphocytes, and from SV40-infected monkey kidney cells. The monkey and human but not guinea pig preparations were effective in inhibiting migration of mastocytoma cells as well as macrophages. This inhibition of migration was not associated with cytotoxicity and was reversible.

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