Lymphokine production in primary mixed lymphocyte culture (MLC) . III. Alloantigen signals cell-cell interactions involved in migration inhibition factor and immune interferon release
Landolfo, S.; Giovarelli, M.; Capusso, A.; Forni, G.
Bollettino dell'Istituto Sieroterapico Milanese 58(2): 128-132
1979
ISSN/ISBN: 0021-2547 PMID: 95480 Document Number: 146359
The alloantigen differences stimulation migration inhibition factor (MIF) and immune interferon (i-IF) release in primary one-way murine mixed lymphocyte cultures are reported. Differences at H-2 and Mls coded alloantigens induce both MIF and i-IF release, while the differences at multiple minor histocompatibility antigens induce MIF release only. Both MIF and i-IF release are T-lymphocytes dependent events. However, while T-lymphocytes are sufficient for MIF release, the presence of macrophages is required for i-IF release.